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Sporadic Creutzfeldt-Jakob disease: beyond central nervous system dysfunction
Sporadic Creutzfeldt-Jacob disease (sCJD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded human prion protein (PrPSc). Classically, sCJD presents with...
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Praxis of a new tool to sharpen neurodegenerative testing
Clinicopathological correlation in dementia subtypes remains challenging, with similar clinical syndromes often caused by different pathologies. With the diagnosis of dementia relying primarily on...
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Jumping, Latah, and Miryachit: understanding neurobiological targets in...
In 1885, Gilles de la Tourette reported several patients with similar movement afflictions that were distinct from true chorea, which, in his case series, he named as the “jumping of Maine, latah of...
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Improving clinical trials in ALS
The clinical trial design is extremely complex in neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS). The clinical and pathological heterogeneity of ALS has made therapeutic...
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Understanding the impact of psychosis in Huntington’s disease
In George Huntington’s original clinical monograph (1872), changes in mental state and behaviour were particularly noted in his description of patients with Huntington’s disease (HD) [1]. Despite the...
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NEUROPSYCHIATRY: Past, Present and Future and into the 21st century
The 30th Anniversary Meeting of the British Neuropsychiatry Association and the Third British Symposium on the History of Neurology and Psychiatry Held at the Royal College of Surgeons, London....
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Armoured with Tendon Hammers: The Neurologist at the Covid-19 Frontline
‘An unseen thief, called Death, came stalking by, Who hereabouts makes all the people die, And with his spear he dove his heart in two And went his way and made no more ado. He’s slain a thousand...
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The Neurology and Neuropsychiatry of COVID-19
SARS-CoV-2 (Credit: CDC / Eckert & Higgins) By Matt Butler, Cameron Watson, Ally Rooney, Jia Song, Jamie Badenoch, Ben Cross, Danish Hafeez, Mao Fong Lim, Hamilton Morrin, Emma Rengasamy,...
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New drugs new adverse effects: Neurology and immune checkpoint inhibitors
Checkpoint inhibitor drugs are a relatively new immunotherapy for cancer, showing outstanding clinical efficacy in various tumors, including lung cancer and melanoma. By improving the immune response...
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From the peas of Mendel: the rise of genetic therapy
At the turn of the 20th Century, observations of human genetic disease largely followed Mendelian principles, based on the crucial experiments of pea hybridization from 1865 (1). Pivotal connections...
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